白质超强度形状与长期痴呆症风险有关
Jasmin Annica Keller1, Sigurdur Sigurdsson2, Kelly Klaassen1
1Department of Radiology, C.J. Gorter MRI Center, Leiden University Medical Center, Leiden, The Netherlands.
概括
不规则的白质超强度 (WMH) 形状和增加的WMH体积与老年人长期痴呆风险更高有关. 这些WMH特征可能有助于预测痴呆症,并指导预防性治疗.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 老年学是一门学科.
背景情况:
- 白质高强度 (WMH) 在老年人中很常见,并与认知能力下降有关.
- 在WMH形态和长期痴呆风险之间的关系需要进一步调查.
研究的目的:
- 检查白质超强度 (WMH) 形状和体积与社区老年人长期发展痴呆症的风险之间的关联.
主要方法:
- 采用了来自3077名参与者的年龄基因/环境敏感性 (AGES) - 雷克雅未克研究的数据.
- 进行了基线1.5T大脑MRI,参与者在痴呆症诊断中平均被跟踪了9.9年.
主要成果:
- 更不规则的WMH形状 (较低的固度,更高的凸度,更高的度指数,更高的碎形维度) 与痴呆症风险增加有关.
- 较高的总WMH体积,周周/流动WMH体积和深深的WMH体积也与长期痴呆风险的增加有显著的关联.
结论:
- 老年人中WMH形状和体积是长期痴呆风险的重要预测因素.
- WMH形状标记可能用于患者预后,并指导预防性痴呆症治疗的选择.
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