阿普雷米拉斯或甲索特雷克萨特:牛皮的箭头在牛皮
Gautam Panda1, Jyoti Prakash Sahoo2, Prasenjeet Mohanty3
1Pharmacology, Sriram Chandra Bhanja Medical College and Hospital, Bhubaneswar, IND.
Cureus
|June 12, 2023
概括
阿普雷米拉斯在治疗牛皮方面显示出比甲状腺素更大的有效性,在六个月内显著改善了牛皮区域和严重性指数 (PASI) 评分. 这两种治疗都被很好地容忍,没有报告任何严重的不良事件.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 在印度次大陆,牛皮的发病率正在上升,气候变化加剧了这种情况.
- 甲托雷克萨特和阿普雷米拉斯特是当前治疗慢性斑块性牛皮的方法.
- 对这些治疗方法的比较研究有限.
研究的目的:
- 为了比较apremilast与甲状腺素对慢性斑块牛皮的疗效和安全性.
- 主要目标:评估6个月后牛皮区域和严重性指数 (PASI) 的变化.
- 二级目标:评估皮肤病生活质量指数 (DLQI) 和不良事件的变化.
主要方法:
- 在印度卡塔克进行了24周的随机,开放的研究.
- 参与者接受的是甲状腺素 (10-15毫克每周一次) 或阿普雷米拉斯 (10-30毫克每天两次).
- 在基线和第8,16和24周评估的有效性和安全性.
主要成果:
- 在85名参与者中,有70人完成了这项研究.
- 与甲状腺素 (-34.75) (p=0.006) 相比,阿普雷米拉斯特显示PASI得分的中位数降低显著更大 (-37.25).
- 在DLQI得分变化中没有显著差异 (p=0.079);没有观察到严重不良事件.
结论:
- 阿普雷米拉斯特在改善牛皮的PASI分数方面表现出了比甲状腺素更高的疗效.
- 这两种治疗都是安全的,耐受性很好,没有严重的不良事件.
- 进一步的研究可能会探索长期的结果和患者报告的生活质量.
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