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不寻常的真菌内分心炎导致移植后传播感染
Waleed Ali1, Bradley Casey2, Ilya Al Salman1
1Cardiology, Cape Fear Valley Medical Center, Fayetteville, USA.
Cureus
|June 12, 2023
概括
在土壤和水中发现的一种真菌Scedosporium apiospermum,可以引起罕见但严重的真菌内心炎. 这一案例突出显示了一名移植患者经历了侵入性感染和不良结果.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
背景情况:
- 性内心炎并不常见,主要影响心内器件或免疫力受损的个体.
- 越来越多地报告Scedosporium apiospermum (S. apiospermum),这是一个机会性真菌病原体.
- 虽然S. apiospermum通常会在免疫能力较强的宿主中引起局部感染,但可以在免疫功能低下的个体中传播,导致危及生命的侵入性感染,抗真菌治疗反应不佳.
研究的目的:
- 描述一个罕见的Scedosporium apiospermum真菌内心炎病例.
- 突出移植接受者免疫抑制剂侵袭性真菌感染的潜力.
- 强调与S. apiospermum内心炎和传播感染相关的不良临床结果.
主要方法:
- 一个移植患者的病例报告.
- 对于真菌败血症感染的临床表现和诊断工作.
- 关于S. apiospermum内心炎的文献综述.
主要成果:
- 该患者出现了S. apiospermum真菌性败血症感染,涉及左心室外流通道 (LVOT).
- 这种感染导致了内心炎和传播疾病.
- 尽管接受了抗真菌治疗,但临床结果不佳.
结论:
- Scedosporium apiospermum可以引起严重的侵入性内心炎,特别是在免疫功能低下的患者,如移植患者.
- 由S. apiospermum引起的侵入性真菌内心炎与传播感染的高风险和预后不佳有关.
- 早期识别和积极管理至关重要,尽管治疗挑战仍然存在.
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