在患有膜心脏病的患者中,L1细胞粘附分子可能是心房动的保护分子
Dayu Wang1, Bo Hu2, Guangtao Xu3
1Department of Cardiology, Guangzhou Panyu Central Hospital, Guangzhou 511400, GD, China.
Heliyon
|June 12, 2023
概括
溶性L1细胞粘附分子 (L1CAM) 水平在心房动 (AF) 患者中降低. 较低的L1CAM表明在膜心脏病中增加了AF风险,这表明它具有保护作用.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 节律失常的研究和研究.
背景情况:
- 心房动 (AF) 是最常见的持续心律失常.
- L1细胞粘附分子 (L1CAM) 涉及至关重要的细胞信号通路.
- 在血清中研究可溶性L1CAM为AF病理生理学提供了洞察力.
研究的目的:
- 为了评估血清溶解L1CAM在AF患者的临床意义.
- 为了确定L1CAM水平与膜心脏病 (VHD) 中的AF之间的关联.
- 评估L1CAM作为AF预测生物标志物的实用性.
主要方法:
- 118名患者的回顾性研究 (有AF/SR的VHD,健康对照).
- 血L1CAM水平通过酶相关免疫吸收试验测量.
- 统计分析包括相关性,多变量逻辑回归和ROC曲线分析.
主要成果:
- 与对照组和鼻节律 (SR) 患者相比,AF患者的血L1CAM水平明显较低.
- L1CAM显示与左心房大小 (LA) 和NT-proBNP.的负相关性.
- 在VHD患者中,L1CAM独立预测了AF风险,提高了预测模型的准确性.
结论:
- 可溶性L1CAM作为VHD患者AF的独立风险指标.
- 将L1CAM纳入预测模型可以提高AF的预测和预测能力.
- 在VHD的背景下,L1CAM可能起到AF的保护因素的作用.
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