离子替代酸盐的抗菌活性:一个系统的审查
Robert Kamphof1, Rui N O Lima2,3, Jan W Schoones4
1Leiden University Medical Center, Department of Orthopaedics, Albinusdreef 2, 2333, ZA, Leiden, the Netherlands.
Heliyon
|June 12, 2023
概括
离子替代酸生物材料显示出显著的抗菌作用. 像银和这样的特定离子显示出强大的细菌减少,为预防感染策略铺平了道路.
科学领域:
- 生物材料科学 生物材料科学
- 抗菌研究 抗菌研究
- 材料化学 材料化学
背景情况:
- 酸生物材料广泛用于骨再生.
- 研究离子替代提供了一条改善生物材料功能的途径.
- 抗菌性质对于预防植入物相关感染至关重要.
研究的目的:
- 量化评估离子替代酸生物材料的抗菌作用.
- 为了确定离子替代和细菌减少的程度之间的关系.
- 为了确定赋予显著抗微生物活性的特定离子.
主要方法:
- 系统的文献搜索到2021年12月.
- 通过使用OHAT工具的两个独立审查员进行研究选择和数据提取.
- 混合效应模型分析,以将离子替代与细菌减少相关联.
主要成果:
- 在1016项已识别的研究中,包括了108项研究.
- 矿,铜,,卢比,加多,银和都显示出抗菌作用.
- 每个原子%的替代物减少细菌数量的日志范围从0.23 () 到10 ().
结论:
- 离子替代显著提高了酸生物材料的抗菌疗效.
- 像银和这样的特定离子表现出相当大的抗菌活性.
- 未来的研究应该集中在体外和体内研究中,以预防周围假肢关节感染 (PJI).
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