基因组学分析支持Mycobacterium tuberculosis在人类和大象之间传播
Rajesh Man Rajbhandari1,2,3,4, Rajindra Napit4, Prajwol Manandhar4
1Departamento de Biologia, Faculdade de Ciencias da Universidade do Porto, Porto, Portugal.
Frontiers in veterinary science
|June 12, 2023
概括
研究了从人类到大象的结核病 (Mycobacterium tuberculosis复合体) 的逆动物传播. 大象和人类的隔离物是密切相关的,支持人与大象的传播,并强调需要一个健康的方法.
科学领域:
- 基因组学就是基因组学.
- 流行病学 流行病学
- 一个健康,一个健康.
背景情况:
- 结核病是由Mycobacterium tuberculosis complex (MTC) 引起的,它在全球范围内影响着人类.
- 人与动物之间MTC的传播已被记录,但反向动物传播 (人畜传播) 的理解较少.
- 亚洲大象 (Elephas maximus) 容易受到MTC感染.
研究的目的:
- 调查尼泊尔MTC动物人类病的可能性.
- 确定来自大象和人类的MTC菌株的进化关系和耐药性概况.
- 评估人类与动物界面对结核病控制的影响.
主要方法:
- 两个亚洲大象和一个人类的MTC菌株的全基因组测序使用Nanopore MinION和Illumina MiSeq.
- 使用非同义单核酸多态性 (SNP) 对齐的族群基因组学分析.
- 使用Tb-Profiler进行药物耐药性变异分析.
主要成果:
- MTC菌株属于第1系 (大象DG),第2系 (大象PK) 和第4系 (人类).
- 在测序的MTC菌株中没有检测到耐药变异.
- 来自大象的MTC分离物在进化上与来自尼泊尔的人类分离物 (血统1和2) 密切相关,支持动物人类病.
- 人类衍生的MTC分离物与国际人体分离物聚集在系4中.
结论:
- 这些发现为尼泊尔动物人类传染病或MTC在人类和大象之间双向传播提供了证据.
- 复杂的宿主-病原体动态需要一个健康策略来预防和控制结核病.
- 综合监测和控制措施至关重要,特别是在人类结核病流行率高的地区.
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