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高压氧对中风后抑郁症的影响

Hong Guo¹, Yi-Ran Ge², Yan-Bin Dong¹

¹Department of Psychology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.

World journal of psychiatry

|June 12, 2023

概括

高压氧 (HBO) 治疗显著改善了糖尿病患者中脑卒中后抑郁症 (PSD) 的抑郁症状和神经功能. 这种治疗也减少了炎症标志物和禁食血糖水平.

科学领域:

神经学神经学
高压医学的高压医学.
糖尿病学糖尿病学

背景情况:

糖尿病患者的中风后抑郁症 (PSD) 存在复杂的挑战,需要控制血糖,情绪和神经系统缺陷.
高压氧疗法 (HBO) 增强组织氧化,可能保护大脑细胞并恢复功能,但其在PSD中的使用尚未研究.

研究的目的:

评估HBO治疗在患有中风后抑郁症 (PSD) 的糖尿病患者的临床疗效.

主要方法:

190名患有PSD的糖尿病患者被随机分为两组:接受埃斯基塔洛普拉姆酸盐的对照组和接受埃斯基塔洛普拉姆酸盐加HBO治疗的观察组.
评估结果使用蒙哥马利-阿斯伯格抑郁症评分表 (MADRS),国家卫生研究院中风量表 (NIHSS) 和实验室标记物,包括过敏C反应蛋白 (hs-CRP),瘤缩因子-α (TNF-α) 和禁食葡萄糖.

主要成果:

这两组在MADRS和NIHSS分数中均显著改善. 与对照组相比,HBO组的NIHSS分数下降幅度更大 (P < 0.001).
比单独标准治疗更有效地显著降低hs-CRP,TNF-α和禁食血糖水平 (P < 0.001).

结论:

对于患有PSD的糖尿病患者来说,HBO疗法提供了显著的好处,改善了抑郁症状和神经功能障碍.
在这种患者群体中,HBO疗法显示出降低炎症和改善血糖控制的潜力.

关键词:

糖尿病糖尿病糖尿病禁食的血葡萄糖禁食的血葡萄糖高压氧疗法高压氧疗法过敏性C反应蛋白过敏性脑卒中后的抑郁症是什么瘤死亡因子-α

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