偏头痛和阿尔茨海默病之间的关联:全国范围的队列研究
Jaeho Kim1, Woo Seok Ha2,3, Sang Hyun Park4
1Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong-si, Republic of Korea.
Frontiers in aging neuroscience
|June 12, 2023
概括
患有偏头痛史的人患阿尔茨海默氏病 (AD) 的风险更高. 这种关联在年轻和肥胖个体中更强烈,突出了AD痴呆的潜在风险因素.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 老年病的医生 老年病的医生
背景情况:
- 偏头痛是一种普遍存在的慢性神经系统疾病.
- 阿尔茨海默病 (AD) 痴呆症是老年人认知能力下降的主要原因.
- 偏头痛和AD风险之间的关系仍未得到充分研究.
研究的目的:
- 调查患有偏头痛病史的患者中阿尔茨海默病 (AD) 的发生率和风险.
- 探索影响这种关联的潜在人口和临床因素.
主要方法:
- 韩国全国医疗保险索赔数据的回顾性分析 (2009年).
- 确定偏头痛 (ICD-10 G43) 和AD (ICD-10 F00,G30) 的诊断.
- 在偏头痛患者和非偏头痛患者之间,AD发病率和风险的比较,调整为年龄和性别.
主要成果:
- 偏头痛患者的AD痴呆发病率较高 (8.0对每1000人年4.1).
- 偏头痛诊断增加了AD痴呆症风险 (危险比率=1.37),特别是在慢性偏头痛患者中.
- 较年轻的年龄 (<65岁) 和较高的BMI (≥25 kg/m2) 与偏头痛患者的AD痴呆风险增加有关.
结论:
- 偏头痛病史与对阿尔茨海默病的易感性增加有关.
- 偏头痛和AD之间的关联在年轻和肥胖个体中更为明显.
- 这些发现表明偏头痛是阿尔茨海默病的潜在风险因素,需要进一步调查.
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