全球DNA甲基化和金属暴露与慢性病之间的关联
Yu-Mei Hsueh1,2, Wei-Jen Chen3, Hui-Ling Lee4
1Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Frontiers in public health
|June 12, 2023
概括
全球DNA甲基化 (5mdC) 与和等金属相互作用,影响慢性病 (CKD) 风险. 5mdC还调解金属对功能的影响.
科学领域:
- 环境健康 环境健康
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 暴露于环境金属是慢性病 (CKD) 的潜在危险因素.
- 全球DNA甲基化,以5-甲基-2-脱氧基丁 (5mdC) 表示,与CKD有关.
- 金属暴露,DNA甲基化和脏健康之间的相互作用需要进一步调查.
研究的目的:
- 检查CKD与全球DNA甲基化 (5mdC) 之间的关联.
- 评估金属暴露 (,,,) 和5mdC与CKD相关的相互作用.
- 探索5mdC在金属暴露和估计的膜过率 (eGFR) 之间的关联中扮演的调解角色.
主要方法:
- 一项涉及218名CKD患者和422名对照者的病例控制研究.
- 测量5mdC (%),血液中的和,血中的和尿液中的.
- 使用后勤和多变量线性回归模型来评估关联,相互作用和调解效应.
主要成果:
- 高血和高5mdC水平与CKD的几率显著增加有关.
- 在血液中的和5mdC之间,以及在血中的和5mdC之间,在CKD风险上发现了积极的相互作用.
- 5mdC水平与血液中的和有关,与血中的相反. 血和血与eGFR的关联部分由5mdC介导.
结论:
- 全球DNA甲基化 (5mdC) 可能与和相互作用,影响CKD风险.
- 5mdC可能会调解金属暴露与功能 (eGFR) 之间的关系.
- 这些发现突显了环境因素,表观遗传学和病之间的复杂相互作用.
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