阿尔多斯特和白细胞相关炎症之间的相关性:初级阿尔多斯特和基本高血压患者之间的比较
Kun-Rui Rao1, Ru-Yi Bao1, Hu Ming1
1Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Journal of inflammation research
|June 12, 2023
概括
原发性阿尔多斯特 (PA) 患者表现出与阿尔多斯特水平相关的明显白细胞炎症模式,与基本高血压 (EH) 患者不同. 这些发现突出了炎症.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 免疫学 免疫学 免疫学
背景情况:
- 原发性阿尔多斯特龙症 (PA) 患者比基本高血压 (EH) 患者面临更高的心血管风险.
- 炎症被怀疑是导致这些风险增加的一个因素.
- 这项研究调查了白细胞炎症标志物与阿尔多素相关的PA与EH之间的关系.
研究的目的:
- 探索白细胞相关炎症参数和血中阿尔多素度 (PAC) 之间的相关性.
- 为了比较PA患者与性别,年龄和血压相匹配的EH患者之间的这些相关性.
主要方法:
- 对346名PA和346名EH患者的回顾性分析.
- 白细胞计数,中性细胞-淋巴细胞比率 (NLR) 和单细胞-淋巴细胞比率 (MLR) 的比较.
- 线性和多变量回归分析以评估与PAC的相关性.
主要成果:
- 与EH患者相比,PA患者的淋巴细胞计数较低,NLR和MLR较高.
- 淋巴细胞计数,NLR和MLR与PA患者的PAC显著且独立相关.
- 这些相关性随着PA中阿尔多素水平的增加而加强,但只有NLR与EH中的PAC相关.
结论:
- 白细胞炎症标志物 (淋巴细胞计数,NLR,MLR) 与PA患者的PAC显著且独立相关.
- 这些相关性依赖于阿尔多斯特,在PA患者中比在匹配的EH患者中更明显.
- 炎症可能在PA中观察到的心血管风险增加中发挥关键作用.
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