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训练有素的天生的免疫力,表观遗传学和食物过敏
Llilian Arzola-Martínez1,2, Catherine Ptaschinski1,2, Nicholas W Lukacs1,2
1Department of Pathology, University of Michigan, Ann Arbor, MI, United States.
Frontiers in allergy
|June 12, 2023
概括
受表观遗传,微生物和代谢因素影响的训练免疫与食物过敏的发展有关. 本综述探讨了益生菌和训练免疫力,以预防严重的过敏并促进耐受性.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏研究 研究过敏
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 在西方文化中,食物过敏发病率的上升与环境因素和免疫调节障碍有关.
- 虽然在食物过敏中适应性免疫力是可以理解的,但先天性免疫变化正在引起人们的注意.
- 环境因素对生命早期的表观遗传和代谢编程影响免疫结果.
研究的目的:
- 审查通过表观遗传,微生物和代谢因素调节训练免疫力.
- 探索训练免疫力和食物过敏发展之间的联系.
- 要总结涉及益生菌和训练免疫的治疗策略,对食物过敏.
主要方法:
- 文献综述侧重于训练免疫力,表观遗传学,微生物组,新陈代谢和食物过敏.
- 分析当前关于益生菌作为治疗干预的研究.
- 检查训练免疫在免疫治疗中的作用.
主要成果:
- 由表观遗传,微生物和代谢因素调节的训练有素免疫力与食物过敏有关.
- 益生菌显示出逆转表观遗传/代谢特征和预防严重食物过敏的潜力.
- 训练有素的免疫可以作为免疫治疗中的诊断/管理策略和机制.
结论:
- 训练有素的免疫力是食物过敏发展的关键因素,受到环境暴露的影响.
- 益生菌为管理和预防食物过敏提供了一个有希望的治疗途径.
- 训练有素的免疫在过敏中提出了新的诊断,管理和治疗目标.
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