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在COVID-19和结核病中控制的人类感染模型:目前的进展和未来的挑战

Hazel Morrison¹, Susan Jackson¹, Helen McShane¹

¹Jenner Institute, University of Oxford, Oxford, United Kingdom.

Frontiers in immunology

|June 12, 2023

概括

控制的人类感染模型 (CHIMs) 正在为结核病和Covid-19研究取得进展. 这些模型有助于研究疾病,测试新的疫苗和治疗方法.

科学领域:

传染性疾病传染性疾病
疫苗学疫苗学疫苗学
免疫学免疫学免疫学

背景情况:

控制人类感染模型 (CHIM) 对于研究疾病进展和评估干预措施至关重要.
针对结核病 (TB) 和Covid-19的CHIM正在开发中,面临着优化挑战.
由于道德考虑,我们需要替代模型来处理毒性病原体,如 Mycobacterium tuberculosis.

研究的目的:

审查结核病和Covid-19的CHIMs的进展和未来方向.
讨论CHIM在了解疾病动力学和免疫反应方面的应用.
突出CHIM在评估新型疫苗和治疗方法中的有用性.

主要方法:

开发使用替代真菌细菌或结核病转基因菌株的CHIM.
使用SARS-CoV-2的鼻腔CHIM来研究病毒动力学和免疫反应.
采用CHIMs的各种管理路径 (气溶,支气管,皮内注射).

主要成果:

CHIM能够详细研究疾病过程,并评估预防/治疗方法.
SARS-CoV-2 CHIMs用于评估病毒动力学和免疫反应.
由于伦理限制,正在开发结核病的替代模型.

结论:

CHIM是推动结核病和Covid-19研究,疫苗开发和治疗评估的重要工具.
对CHIM的持续改进对于其有效应用至关重要.
COVID-19大流行的动态性质为CHIM发展带来了独特的挑战和机会.

关键词:

奇姆奇姆奇姆在 COVID-19 疫情中,挑战模型挑战模型控制的人类感染.结核病是一种肺结核病.

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