在患有绝经前恐慌症的患者中改变了肠道微生物群的特征
Shen Lin1, Hongjin Wang1, Jingjing Qiu1,2
1Clinical Medical College of Acupuncture-Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Frontiers in psychiatry
|June 12, 2023
概括
绝经前恐慌症 (PPD) 与肠道细菌的变化有关,特别是减少多样性和细菌类和型的变化. 这种微生物失衡可能是PPD发展的关键,并提供了新的诊断和治疗目标.
科学领域:
- 微生物组研究的研究.
- 妇女的心理健康妇女的心理健康
- 胃肠病学 胃肠病学
背景情况:
- 绝经前恐慌症 (PPD) 显著影响女性的健康和功能.
- 目前对PPD的药物治疗是有限的,其潜在机制仍然不清楚.
- 新出现的证据将肠道微生物群与情绪调节联系起来,但其在PPD中的作用基本上是未知的.
研究的目的:
- 在PPD患者中识别特定的肠道微生物群变化.
- 调查肠道微生物群组成和PPD之间的关系.
- 探索PPD潜在的诊断标志物和治疗点.
主要方法:
- 16S rRNA测序用于分析40名PPD患者和40名健康对照者的肠道微生物群.
- 分析包括α-多样性 (丰富性) 和β-多样性 (组成) 的评估.
- 在微生物丰富度和临床尺度 (HAMA,PDSS,PASS) 之间进行了相关性分析.
主要成果:
- 与对照组相比,PPD患者的肠道微生物α多样性显著减少.
- 在PPD患者和健康个体之间观察到不同的肠道微生物组合 (β-多样性).
- 30种细菌属的丰度有显著差异; 细菌类和类与PPD症状严重程度尺度有正相关性.
结论:
- 细菌菌和菌菌的失生症是PPD中不平衡的肠道微生物群的突出特征.
- 这些微生物变化代表了潜在的致病因子和PPD的病理生理学特征.
- 在PPD患者中,独特的肠道微生物群概况提供了作为诊断生物标志物和新治疗点的潜力.
相关概念视频
Panic Disorder
146
Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
146
Irritable Bowel Syndrome I: Introduction
326
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
326
Anorexia Nervosa
155
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
155
Stress and Mental Health
186
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
186


