在恐慌障碍中抗抑郁药引起的躁狂:对临床和功能连接性特征的单一病例研究
Byung-Hoon Kim1,2, Seung-Hyun Kim3, Changsu Han3
1Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea.
Frontiers in psychiatry
|June 12, 2023
概括
在恐慌障碍患者中,抗抑郁药诱导的躁狂可能是通过改变杏仁体连接性来预测的. 这项研究在患有躁狂症的患者中确定了特定的大脑连接差异,为风险评估提供了潜在的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 恐慌症 (PD) 是常见的,通常与其他心理健康状况同时发生.
- 对PD的抗抑郁药治疗具有20-40%的诱导躁狂的风险.
- 对焦虑症患者的躁狂相关的临床和神经学因素的研究有限.
研究的目的:
- 在患有躁狂症的恐慌失调患者中,调查基于杏仁体的大脑连接的改变.
- 为了比较患有恐慌障碍,患有躁狂症 (PD-manic) 和没有躁狂症 (PD-NM组) 的患者之间的大脑连接.
- 探索潜在的神经生物标志物用于抗抑郁药诱导的躁狂恐慌症.
主要方法:
- 一项前性研究将一名PD躁狂患者与PD-NM组 (没有发展躁狂的恐慌症患者) 进行比较.
- 使用以种子为基础的全脑方法分析静止状态的功能连接,重点是杏仁体.
- 进行了探索性ROI-to-ROI分析,将PD组与健康对照组 (HCs) 进行比较.
主要成果:
- 与PD-NM组相比,PD-Manic患者在默认模式和前对对联网络中的连接性较低,在视觉处理网络中的连接性更高.
- 在PD躁狂患者中观察到左侧中间旋和右侧杏仁体之间的休息状态功能连接性增加.
- 在PD-躁狂组中发现了PD组和HC之间的连接性显著差异,但在PD-NM组中没有.
结论:
- 与默认模式网络和前对对联网络的杏仁体连接的改变在患有抗抑郁药引起的躁狂症的恐慌症患者中很明显.
- 基于杏仁体的静止状态功能连接可能作为预测抗抑郁药诱导的躁狂恐慌症的潜在生物标志物.
- 需要对更大的队列进行进一步的研究,以验证这些发现,并扩大对抗抑郁药引起的躁狂的理解.
关键词:
阿米格达拉的桃体抗抑郁剂诱导的躁狂是抗抑郁剂诱导的躁狂.生物标志物 生物标志物双相情感障碍是双相情感障碍的一种疾病.默认模式网络模式 默认模式网络模式前沿平行网络的前沿.恐慌失调是一种恐慌失调.静止状态的功能连接.更多相关视频
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