确定风险因素,并开发宫癌患者术后盆底功能障碍的预测模型
Yuan-Yuan Liu1, Wen-Hui Zhu2, Wei Li1
1Department of Gynecology, Qingdao Fifth People's Hospital, Qingdao, China.
Translational cancer research
|June 12, 2023
概括
盆地功能障碍在宫癌手术后很常见. 关键的风险因素包括65岁以上的年龄,开放性手术,全腹切除术和放射治疗,有助于识别高风险患者.
科学领域:
- 妇科 妇科医生 妇科
- 在瘤学瘤学.
- 泌尿和妇科 泌尿和妇科
背景情况:
- 盆地功能障碍 (PFD) 是宫癌手术后的常见并发症.
- 早期识别风险因素和高风险患者对于PFD预防和管理至关重要.
研究的目的:
- 研究宫癌患者手术后与PFD相关的风险因素.
- 开发一种预测模型,用于识别患有PFD高风险的患者.
主要方法:
- 一项对282名接受手术的宫癌患者的回顾性研究.
- 根据手术后6个月的PFD发展情况,患者被分为PFD (n=92) 和对照 (n=190) 组.
- 分析了临床特征,以确定风险因素,并使用统计软件建立预测模型.
主要成果:
- 两组之间观察到年龄,手术方法,切除范围和放射治疗的显著差异 (P<0.05).
- 确定了风险因素:年龄>65岁,开放性手术,全腹切除术和放射治疗 (P<0.05).
- 预测模型显示训练组的AUC为0.755,验证组的AUC为0.604,并且很适合 (Hosmer-Lemeshow P=0.341).
结论:
- 手术后的PFD在宫癌患者中非常普遍.
- 65岁以上的年龄,开放式手术,整体子宫切除术和放射治疗是PFD的重要风险因素.
- 开发的模型有助于早期识别患有高风险的宫癌患者.
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