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结合Tb和Gd可以提高磁触性细菌的诊断功能

Lucía Gandarias¹, Elizabeth M Jefremovas^2,3, David Gandia⁴

¹Dpto. Inmunología, Microbiología y Parasitología, Universidad del País Vasco (UPV/EHU), Leioa, 48940, Spain.

Materials today. Bio

|June 12, 2023

概括

磁力战术细菌被设计成作为theranostic的纳米机器人. 修改后的细菌提供了增强的诊断能力,作为光生物标志物和磁共振成像 (MRI) 的双对比剂.

科学领域:

生物技术是生物技术.
微生物学微生物学
纳米医学是一种纳米医学.

背景情况:

磁策动细菌具有内在的运动性和磁性,使得它们可以被用作目标纳米机器人.
现有的研究探索了它们的潜力,以结合诊断和治疗来进行治疗学应用.
磁螺旋 (Magnetospirillum gryphiswaldense MSR-1) 是一种用于研究磁触性细菌的模型生物.

研究的目的:

为了增强Magnetospirillum gryphiswaldense MSR-1的诊断功能.
为了将兰坦化物 (和) 纳入磁触细菌,用于新型成像和生物标记应用.
为了评估修改后的磁触性细菌的异能潜力.

主要方法:

在补充 (Tb) 或 (Gd) 的介质中培养Magnetospirillum gryphiswaldense MSR-1.
描述Tb-纳入细菌 (Tb-MSR-1) 的发光特性.
评估Gd-纳入细菌 (Gd-MSR-1) 的磁共振成像 (MRI) 对比增强.
在两个细胞模型中对修饰细菌进行体外试验.

主要成果:

结合Tb,赋予MSR-1发光,适用于生物标志物应用.
通过Gd的结合,创建了MRI的双重对比剂,将T1对比度添加到固有的T2对比度中.
修改后的MSR-1菌株在体外细胞模型中表现出成功的诊断能力.
Tb-MSR-1证实了作为光标记物的适用性,Gd-MSR-1作为MRI的双对比剂.

结论:

磁策动细菌可以用兰化物进行工程设计,以获得先进的诊断功能.
修改后的MSR-1细菌显示出作为在体内应用的多功能神经解剖剂的前景.
这项研究扩大了磁触细菌在生物医学成像和诊断方面的实用性.

关键词:

发光标记物是发光的标记物.磁性高热症是一种磁性高热症.磁共振成像技术磁共振成像技术磁触性细菌是一种磁触性细菌.治疗神经的代理商.在X射线吸收光谱检测中使用X射线吸收光谱.

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