在非酒精性脂肪性肝病患者中,阿波利波蛋白C3多态和脂肪摄入之间的营养学相互作用
Reina Yamamoto1, Yumie Takeshita1, Hiromasa Tsujiguchi2
1Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Current developments in nutrition
|June 12, 2023
概括
在日本成年人中,阿波利波蛋白C3基因 (APOC3) 和高脂肪摄入量的遗传变异与非酒精性脂肪性肝病 (NAFLD) 风险有关. 个性化的营养策略应该考虑这些营养基因相互作用.
科学领域:
- 营养遗传学 营养遗传学
- 代谢疾病 代谢疾病
- 基因组学就是基因组学.
背景情况:
- 全基因组关联研究确定了与非酒精性脂肪肝疾病 (NAFLD) 相关的遗传多态性.
- 遗传变异,营养代谢和NAFLD病原体之间的相互作用需要进一步研究.
研究的目的:
- 调查营养因素与NAFLD发展中的遗传倾向之间的相互作用.
- 识别导致NAFLD风险的特定基因多态和饮食成分.
主要方法:
- 对464名日本成年人 (≥40岁) 的健康检查数据的分析,使用腹腔声谱来诊断NAFLD.
- 通过简短的自我管理的饮食史问卷评估饮食摄入量.
- 使用Japonica Array v2识别NAFLD相关的基因多态,专注于阿波利波蛋白C3 (APOC3) 基因.
主要成果:
- 在APOC3基因中的T-455C多态性 (rs2854116) 与NAFLD有显著的关联,异构菌体的患病率更高.
- 在NAFLD和脂肪摄入之间发现了显著的相互作用,包括植物脂肪,MUFA,PUFA,胆固醇,n-3FA和n-6FA.
- 与没有NAFLD的人相比,患有NAFLD和rs2854116的TT基因型的人的脂肪摄入量显著增加.
结论:
- APOC3基因多态 (rs2854116) 和高脂肪摄入量是与日本成年人NAFLD风险相关的关键因素.
- 存在营养遗传相互作用,其中具有rs2854116的TT基因型和NAFLD的个体消耗更多的脂肪.
- 了解这些遗传和饮食相互作用对于开发针对NAFLD管理的个性化营养干预措施至关重要.
相关概念视频
Lipid Catabolism
102
Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
102
Atherosclerosis III: Management
15
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
15
Cholesterol: Significance and Regulation
606
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
606
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
713
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
713


