在腹腔透析患者中开发和验证一个名录图来预测蛋白质能量浪费:一个多中心队列研究
Ziwei Mei1, Bin Zhu2, Xiaoli Sun1
1Lishui Municipal Central Hospital, Lishui, China.
PeerJ
|June 12, 2023
概括
蛋白质能量浪费 (PEW) 在腹腔透析 (PD) 患者中很常见. 一个新的名图有效地利用年龄和CRP等因素预测PEW风险,帮助预防和临床决策.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床营养学 临床营养学
- 生物统计学 生物统计学
背景情况:
- 蛋白质能量浪费 (PEW) 是经过腹膜透析 (PD) 的患者经常出现的并发症.
- 有限的研究存在于确定风险因素和开发预测模型的PEW在这个人群中.
- 这项研究的目的是创建一个预测的PEW风险在PD患者PEW的nomogram.
研究的目的:
- 开发和验证用于预测腹膜透析 (PD) 患者中蛋白质能量浪费 (PEW) 风险的诺姆图.
- 在PD患者群体中确定与PEW相关的关键临床和生化预测因素.
- 为 PEW 提供早期风险评估和干预策略的工具.
主要方法:
- 在2011年至2022年期间,从369名末期病患者 (ESRD) 收集了PD的回顾性数据.
- 多变量逻辑回归分析以识别预测因素并构建名ogram.
- 使用接收机操作特征 (ROC) 曲线,校准图表和决策曲线分析 (DCA) 的性能评估.
主要成果:
- 在研究队列中,PEW的发病率为49.86%.
- 确定的预测因素包括年龄,透析持续时间,葡萄糖,C反应蛋白 (CRP),肌素清除率 (Ccr),血清肌素 (Scr),血清和甘油三 (TG).
- 命名图表显示出良好的分辨率 (ROC 0.769在开发中,0.669在验证中) 和适当的校准.
结论:
- 开发的名图是预测PD患者PEW风险的宝贵工具.
- 这种预测模型可以为临床决策提供信息,并指导PEW的预防.
- 需要进一步的验证和前性研究来证实其临床实用性.
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