肝素结合蛋白和D-Dimer在败血症患者中的预测价值
Jian Tang1, Hong Yuan2, Yun Long Wu1
1Department of Intensive Care, First People's Hospital of Linping District, Hangzhou, Zhejiang Province, People's Republic of China.
International journal of general medicine
|June 12, 2023
概括
对肝素结合蛋白 (HBP) 和D-二次体的连续测量可以预测败血症患者的28天死亡率. 结合HBP和D-二次体,为预后和治疗评估提供了卓越的有效性.
科学领域:
- 关键护理医学 关键护理医学
- 生物标志物发现发现
- 败血症病理生理学病理生理学
背景情况:
- 败血症是一种危及生命的疾病,需要准确的预后标志物.
- 早期识别高风险败血症患者对于及时干预至关重要.
- 肝素结合蛋白 (HBP) 和D-二次体是败血症的潜在生物标志物.
研究的目的:
- 评估HBP和D-二次体的序列测量,以预测严重病情的败血症患者的28天死亡率.
- 评估HBP和D-二次体作为预后指标的疗效.
- 为了确定HBP,D-二次体和疾病严重程度 (SOFA分数) 之间的相关性.
主要方法:
- 一组51名败血症患者被分为生存和死亡组.
- 在第一,第三和第五天测量了HBP和D-二元水平.
- 顺序性器官衰竭评估 (SOFA) 评分在入院时被记录下来.
- 统计分析包括相关性和预测有效性评估.
主要成果:
- 在生存组 (P<0.05) 中观察到较低的HBP和D-二聚体水平和SOFA得分.
- HBP和D-二聚体水平与SOFA得分正相关 (P<0.05).
- 结合HBP和D-二次体显示高预测值 (AUC=0.830) 具有68.42%的灵敏度和92.31%的特异性.
结论:
- HBP和D-二聚体显示出对败血症预后的显著预测效果.
- 结合HBP和D-体测量可以提高预测准确度.
- 这些生物标志物可以用于预测28天死亡率和对败血症患者的疗效评估.
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