在2型糖尿病病中血清甲素S的诊断值
Xuejing Ren1,2, Wanqing Wang3, Huixia Cao1
1Henan Key Laboratory of Kidney Disease and Immunology, Henan Provincial Clinical Research Center for Kidney Disease, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Frontiers in endocrinology
|June 12, 2023
概括
甲素S (Cat-S) 是糖尿病病 (DKD) 的新型风险因素,并且比囊素C更好的诊断标志物. 监测Cat-S有助于早期DKD查和严重程度评估.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 生物化学 生物化学
背景情况:
- 糖尿病病 (DKD) 对糖尿病患者构成重大威胁,需要早期检测和干预策略.
- 血管内皮功能障碍的标志物Cathepsin S (Cat-S) 具有作为DKD非侵入性诊断工具的潜力,尽管临床数据有限.
研究的目的:
- 调查Cathepsin S (Cat-S) 作为糖尿病病 (DKD) 的潜在危险因素.
- 评估血清Cat-S水平的诊断性能,以识别DKD.
主要方法:
- 用ELISA测量了43名健康人群和200名2型糖尿病患者的血清Cat-S水平.
- 使用斯皮尔曼相关性分析了血清Cat-S和临床指标 (尿中白蛋白与肌素的比率,估计的淋巴膜过率) 之间的相关性.
- 多变量逻辑回归在T2DM患者中确定了DKD和功能下降的风险因素.
主要成果:
- 血清Cat-S水平与白蛋白尿 (r=0.76) 有正相关性,与估计的淋巴膜过率 (r=-0.54) 有负相关性.
- 血清Cat-S和囊素C (CysC) 的升高被确定为DKD和功能下降的独立风险因素.
- 与CysC (AUC=0.791) 相比,血清Cat-S显示了DKD的更高的诊断准确性 (AUC=0.900).
结论:
- 血清Cat-S的增加与T2DM患者的白蛋白尿进展和功能下降有关.
- 血清Cat-S对DKD的诊断值高于CysC. 血清Cat-S对DKD的诊断值高于CysC.
- 监测血清Cat-S可能为早期DKD查和严重程度评估提供一个新的策略.
相关概念视频
01:26Nephrotic Syndrome II : Assessment and Medical Management
10
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
10
01:24Serum Studies: Renal Function Tests
24
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
24
01:28Chronic Kidney Disease III: Interprofessional Care
50
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
50
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
40
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
40
01:25Chronic Kidney Disease I: Introduction
43
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
43
01:24Chronic Kidney Disease II: Clinical Manifestations
42
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
42