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Eat4Genes:一个生物信息理性基因向应用程序和原型模型,用于改善人类健康

Morgan L Ford¹, Jessica M Cooley¹, Veda Sripada²

¹Department of Mathematical Sciences, Rensselaer Polytechnic Institute, Troy, NY, United States.

Frontiers in nutrition

|June 12, 2023

概括

饮食理性基因向 (DRGT) 使用饮食来调节基因表达. 开发了一个互动应用程序Eat4Genes,以指导用户选择基因表达调节和健康改善的食物.

科学领域:

营养基因组学营养基因组学
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

饮食理性基因向 (DRGT) 是一种使用饮食成分规范疾病相关基因表达的策略.
这种方法强调整个食物及其生物活性化合物具有治疗益处.
了解饮食对基因表达的调节对于开发新的健康干预措施至关重要.

研究的目的:

确定在摄入饮食剂后对基因表达变化的人类研究,重点关注全食食品.
开发一个交互式在线应用程序原型,Eat4Genes,以指导用户对基因表达调节的饮食干预措施.
促进将DRGT战略转化为公共卫生资源.

主要方法:

在多个数据库 (GEO,PubMed,Google Scholar等) 中使用"人类"",基因表达"和51种食剂等关键词进行系统的文献搜索. ) 的情况.
对基因调制效应的已确定的研究进行评估.
使用R-Shiny平台开发"Eat4Genes"互动应用程序.

主要成果:

确定了51个人类摄入研究 (37个与全食相关) 和96个关键风险基因.
研究的41种全食物或提取物中的18种发现了基因表达数据.
Eat4Genes应用程序允许用户选择条件或基因,以提供量身定制的食物建议,可视化和数据链接.

结论:

一个交互式饮食指南应用程序原型,Eat4Genes已经成功开发.
该应用程序是将DRGT战略转化为实际的公共卫生工具的重要一步.
开发的资源旨在成为通过饮食基因调制改善健康的创新,低成本和可访问的选择.

关键词:

应用程序应用程序应用程序生物信息学是一种生物信息学.饮食指南饮食指南饮食理性的基因向基因表达的基因表达方式医疗保健医疗保健医疗保健医疗保健健康的饮食制剂健康的饮食制剂风险基因风险基因风险基因

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