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视网膜微血管和微结构变化在皮肤肌炎的诊断:一种新的方法

Bo-Zhi Huang¹, Qian Ling¹, San-Hua Xu¹

¹Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Frontiers in medicine

|June 12, 2023

概括

光学连贯断层扫描血管造影显示,皮肤肌炎患者的视网膜厚度和表面血管密度降低. 这种成像技术可以帮助监测皮肤肌炎患者的眼睛并发症,包括患有间歇性肺部疾病的患者.

科学领域:

眼科医生眼科眼科
类风湿病学类风湿病学
医疗成像医学成像

背景情况:

皮肤肌肉炎 (DM) 是一种自身免疫性疾病,可以影响包括眼睛在内的各种器官.
在DM的眼部表现可以包括微血管变化和视网膜变化.
早期发现和监测这些变化对于管理疾病至关重要.

研究的目的:

调查底部变化 (视网膜厚度,微血管变化) 和皮肤肌炎 (DM) 之间的关系.
评估光学连贯断层扫描血管学 (OCTA) 在评估DM中的眼部参与方面的实用性.

主要方法:

一项涉及16名DM患者和16名健康对照者的比较研究.
使用OCTA分析底部数据,根据早期治疗糖尿病视网膜病变研究的子区域将其划分为层和区域.
在DM患者和HC患者之间比较了视网膜厚度 (RT) 和表面血管密度 (SVD).

主要成果:

与HC相比,DM患者在多个区域的全视网膜厚度 (RT) 和内层RT显著降低.
在所有评估区域的DM患者中,表面血管密度 (SVD) 显著降低.
内下部 (II) 区域对DM病理变化的诊断敏感度很高,曲线下的面积 (AUC) 为RT的0.9028,SVD的0.9634.

结论:

光学连贯断层扫描血管造影 (OCTA) 有效地检测皮肤肌炎 (DM) 的眼睛病变.
可以使用OCTA监测DM患者的疾病进展和眼部并发症,包括患有间歇性肺病的患者.

关键词:

皮肤肌肉性炎 (DM)间歇性肺病间歇性肺病光学连贯性断层扫描血管图谱视网膜的厚度视网膜的厚度船舶密度是指船舶的密度.

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