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RNA降解对纳米孔直接RNA测序的普遍影响

Yair D J Prawer1, Josie Gleeson1, Ricardo De Paoli-Iseppi1

  • 1Centre for Stem Cell Systems, Department of Anatomy and Physiology, The University of Melbourne, Parkville, VIC, 3010, Australia.

NAR genomics and bioinformatics
|June 12, 2023
PubMed
概括

直接RNA测序 (DRS) 可能因RNA降解而产生偏差,影响基因表达测量. 然而,显式校正方法可以恢复生物信号,使得DRS适用于部分降解的样品.

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