基于酸盐衍生物和氧化酸酸盐的自我交叉连接水凝的制备方法和特性
Guiting Yu1, Chunqing Niu2, Jiali Liu1
1College of Chemistry and Material Sciences & School of Life Sciences, Heilongjiang University, Harbin, Heilongjiang 150080, China.
ACS omega
|June 12, 2023
概括
这项研究介绍了一种由N-2-基三甲基氨化基 (HACC) 和氧化藻酸盐 (OSA) 制成的快速形成,生物相容的水凝. 由此产生的HACC/OSA水凝具有出色的机械性能,抗菌活性,并具有用于组织工程的药物持续释放潜力.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 聚合物化学 聚合物化学
背景情况:
- 生物相容的水凝对于组织工程应用至关重要.
- 开发自我交叉连接的水凝简化了制造过程,并提高了材料的性能.
- 酸盐和酸盐衍生物为生物医学用途提供可调节的特性.
研究的目的:
- 开发一种使用N-2-基三甲基氨化基 (HACC) 和氧化藻酸盐 (OSA) 的新型,自我交叉连接,生物相容的水凝.
- 研究HACC/OSA水凝的形成机制,结构特征,机械性能和生物功能.
- 评估HACC/OSA水凝作为药物输送和组织再生的生物医学载体的潜力.
主要方法:
- 通过化学修饰来制备HACC和OSA.
- 制造HACC/OSA水凝,使用与结合的希夫基自交联反应,以NaCl作为屏蔽剂为辅助.
- 描述水凝结构 (多孔性),机械性能 (压缩,弹性),胀行为,生物降解和保持水分.
- 对抗黄金葡萄球菌和大肠杆菌的抗菌活性的评估.
- 细胞相容性和药物持续释放 (罗达胺) 能力的评估.
主要成果:
- 一种均的HACC/OSA水凝通过Schiff基交联和结迅速 (在74秒内) 形成.
- 水凝具有均的多孔结构,增强机械性能和良好的弹性.
- 观察到有利的胀,生物降解和保持水分的特性.
- 证明了对S. aureus和E. coli的显著抗菌活性.
- 证实了良好的细胞兼容性和有效的罗达胺持续释放.
结论:
- 开发的HACC/OSA水凝是一种快速形成,生物相容,可生物降解的材料,具有出色的机械和抗菌性能.
- 希夫基交联机制,在NaCl的帮助下,允许控制凝的形成和提高均性.
- 这些HACC/OSA水凝显示出在组织工程中的应用和作为药物输送的生物医学载体的巨大潜力.
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