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Updated: Jul 26, 2025

Generation of Null Mutants to Elucidate the Role of Bacterial Glycosyltransferases in Bacterial Motility
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解读蛋白质O-GalNAcylation:方法开发和疾病影响

Shuang Yue1,2, Xiaotong Wang3,2, Wei Ge1

  • 1Center for Clinical Mass Spectrometry, Department of Pharmaceutical Analysis, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China.

ACS omega
|June 12, 2023
PubMed
概括

类型O-糖化,特别是截断的O-糖化 (Tn抗原),对于粘膜壁垒至关重要,但其调节失调与疾病有关. 新的分析方法正在出现,以研究这个具有挑战性的甘氨酸.

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Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
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