优化基托桑装饰的固体脂质纳米颗粒,以改善flurbiprofen通过皮肤传递
Firdous Ahmad Burki1, Kifayat Ullah Shah1, Ghulam Razaque2
1Particle Design and Drug Deliveryery Laboratory, Faculty of Pharmacy, Gomal University, Dera Ismail Khan 29050, Khyber Pakhtunkhwa, Pakistan.
ACS omega
|June 12, 2023
概括
酸盐涂层的固体脂质纳米颗粒 (SLN) 增强了非类固醇抗炎药物 (NSAID) 弗鲁比的通过皮肤传递. 这些新的配方改善了药物透,为口服提供了有希望的替代品.
科学领域:
- 纳米技术纳米技术
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 通过皮肤递送药物为导致胃肠道不适的药物提供了口服药物的替代方案,如flurbiprofen.
- 非类固醇抗炎药物 (NSAIDs) 可能导致胃部问题,需要使用替代的输送方法.
- 固体脂质纳米粒子 (SLNs) 正在研究改善药物递送特性.
研究的目的:
- 为了设计和表征flurbiprofen的素涂层SLN透皮配方.
- 评估基托桑涂层对SLN特性和药物释放的影响.
- 为了评估flurbiprofen从基托涂层的SLN通过切割的老鼠皮肤通过皮肤透.
主要方法:
- 使用溶剂乳化方法制备SLN.
- 用不同度的奇托 (0.05%,0.10%,0.20%) 涂上SLN的涂层.
- 粒子大小的表征,药物协同效率,药物释放动力学和体外皮肤透.
主要成果:
- 酸盐涂层增加了SLN颗粒大小,较高度导致更大的颗粒.
- 药物关联效率随着基托桑度的增加而改善,这是由于增加了flurbiprofen-chitosan亲和力.
- 与未涂层SLN相比,桑涂层SLN表现出显著更高的通过皮肤透和延迟的药物释放,在非Fickian异常扩散之后.
结论:
- 酸盐涂层的SLN代表了一种可行的载体系统,可以通过皮肤输送flurbiprofen.
- 这些配方通过增强药物透,显示出改善治疗结果的潜力.
- 这项研究为推进超越传统方法的透皮药物递送系统提供了洞察力.
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