体殖民减少了Pseudomonas aeruginosa的负担和随后的气道损伤
Sara N Stoner1, Joshua J Baty1, Lea Novak1
1Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Frontiers in cellular and infection microbiology
|June 12, 2023
概括
在囊性纤维化呼吸道中Streptococcus salivarius殖民减少了Pseudomonas aeruginosa的负担和宿主炎症. 这表明S. salivarius可能通过调节微生物社区和免疫反应来改善肺功能.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 肺部医学 肺部医学
背景情况:
- Pseudomonas aeruginosa 是囊性纤维化 (CF) 呼吸道的主要病原体,导致死亡率.
- 口腔链球菌的殖民,特别是Streptococcus salivarius,与稳定的CF肺功能相关.
- 在各种模型中,S. salivarius已经证明了抗炎性质.
研究的目的:
- 调查S. salivarius在CF的背景下可以改善肺功能的机制.
- 确定S. salivarius和P. aeruginosa联合感染对大鼠模型中的细菌殖民和宿主炎症反应的影响.
主要方法:
- 在使用P. aeruginosa和S. salivarius的老鼠中的同时感染模型.
- 肺组织组织组织学分析炎症和损伤.
- 预炎性细胞因子 (IL-1β,IL-6,CXCL2,TNF-α) 的量化.
- 在合成CF唾液中共培养细菌的RNA测序.
主要成果:
- 双重感染增强了S. salivarius的殖民化,减少了P. aeruginosa的殖民化.
- 在同时感染的老鼠中,炎症和损伤的组织学评分较低.
- 在共感染期间,促炎性细胞因子的下调显著.
- 在体外,S. salivarius的存在下调了P. aeruginosa的葡萄糖代谢基因.
结论:
- 在P. aeruginosa的共感染期间促进了S. salivarius的殖民化.
- P. aeruginosa的细菌负担和相关的宿主炎症被S. salivarius减少.
- S. salivarius可能通过改变P. aeruginosa的健康状况和减轻炎症来改善CF肺部健康.
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