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在古生物中的假定基于核酸的第二信使

Chris van der Does¹, Frank Braun¹, Hongcheng Ren¹

¹Molecular Biology of Archaea, Institute of Biology, University of Freiburg, 79104 Freiburg, Germany.

|June 12, 2023

概括

考古生物利用基于核酸的第二信使进行细胞信号传输,循环二-AMP和循环基酸分别在透调节和抗病毒防御中发挥了明确的作用. 需要进一步的研究来阐明其他已识别的信使的功能.

科学领域:

微生物学微生物学
分子生物学分子生物学
生物化学生物化学

背景情况:

第二信使对于生命的各个领域的信号传导至关重要.
基于核酸的第二信使在细菌和真核生物中具有很好的特征.
古代生物也拥有基于核酸的第二信使,但它们的作用不太清楚.

研究的目的:

审查和总结当前对古生物中的基于核酸的第二信使的理解.
突出已知的功能,并确定需要进一步调查的领域.

主要方法:

关于考古第二信使研究的文献综述.
对不同古生物学类和与细菌/真核生物的第二信使系统进行比较分析.

主要成果:

循环二-AMP (cd-AMP) 参与了Euryarchaea的透调节,类似于它在细菌中的作用.
循环橄基酸盐是CRISPR-Cas系统的关键激活剂,用于古生物的抗病毒防御.
已经确定了其他几种循环核酸和二核酸,但它们的功能和途径在很大程度上仍然未被阐明.
3'-3'-cGAMP的合成酶存在于Euryarchaea中,尽管没有检测到该分子本身.
细菌的第二信使周期性迪加诺辛单酸盐 (cdGMP) 和瓜诺辛多酸盐 (ppGpp/pApp) 在古生物中不存在.

结论:

基于核酸的第二信使在古生物中扮演着不同的角色,包括透调节和免疫力.
虽然一些信使的定义很好,但许多需要进一步的功能和通路特征.
古代生物拥有独特的第二信使,在某些方面与细菌不同.

关键词:

考古学是指古物质 (archaea) 是指古物质.循环的二甲基乙烯酸.循环性橄甲酸酸.第二个信使是第二个使者.信号传输,信号传输.

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