在帕金森病中与焦虑有关的大脑恐惧回路内的功能连接改变:基于种子的功能连接研究
Kaidong Chen1, Li Zhang2, Feng Wang2
1Department of Radiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, No. 299, Qingyang Road, Liangxi District, Wuxi, 214023, Jiangsu Province, China.
Heliyon
|June 12, 2023
概括
帕金森病 (PD) 中的焦虑与杏仁体中功能连接 (FC) 的改变有关. 这些大脑连接的变化可能解释了PD患者焦虑的神经基础.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 帕金森病 (PD) 是一种神经退行性疾病.
- 焦虑是PD患者常见的并发症.
- 在PD中焦虑的神经支尚未完全理解.
研究的目的:
- 在患有焦虑症的PD患者中,研究杏仁体和其他大脑区域之间的异常功能连接 (FC).
- 探索杏仁体FC与PD焦虑严重程度之间的关系.
主要方法:
- 预期招募PD患者和健康对照组.
- 使用汉密尔顿焦虑评分 (HAMA) 尺度对焦虑的评估.
- 休息状态功能性MRI (rs-fMRI) 来分析杏仁体FC模式.
主要成果:
- 与非焦虑PD患者和对照人群相比,焦虑PD患者与海马体,布塔门体,内突体和前体表现出改变的杏仁体FC.
- 在PD患者中,杏仁体-海马体FC与HAMA得分负相关 (r = -0.459,p = 0.007).
结论:
- 研究结果支持恐惧回路参与焦虑PD中的情绪调节.
- 异常的杏仁体FC模式提供了对帕金森病焦虑神经机制的初步见解.
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