酸气溶用于呼吸道同胞性病毒的吸入治疗
Anjie Feng1, Jieyu Li1, Yu Hu1
1Shandong University of Traditional Chinese Medicine, Jinan 250000,China.
酸 (CA) 对呼吸道同胞病毒 (RSV) 是有前途的,但口服吸收不佳. 开发一种计量剂量吸入器 (MDI) 配方可提高药物输送到肺部,以有效治疗RSV.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物输送系统 药物输送系统
- 呼吸系统医学 呼吸系统医学
背景情况:
- 酸 (CA) 是咖啡酸的衍生物,具有强大的抗呼吸综合体病毒 (RSV) 活性,具有低毒性.
- 口服生物可用性和肠道吸收性差,限制了CA在口服配方中的治疗潜力.
- 针对性向呼吸道输送对于有效的基于CA的RSV治疗至关重要.
研究的目的:
- 开发和优化酸 (CA) 的计量剂量吸入器 (MDI) 配方,以增强呼吸传递.
- 确定最佳配方成分并描述CA-MDI的气溶特性.
- 评估开发的CA-MDI的质量和初步稳定性.
主要方法:
- 配方开发涉及基于清晰度和稳定性的潜溶剂选.
- 使用单因子和直角实验设计优化潜溶剂含量.
- 气溶属性的表征和最终CA-MDI配方的初步稳定性研究.
主要成果:
- 最佳的CA-MDI配方包括CA (15毫克),绝对乙醇 (1克),乙醇 (0.4克) 和1,1,1,2-四乙烯 (10克).
- 准备好的MDI被指定为每瓶含有150次启动,每次启动提供75μg的CA.
- 质量控制测试证实,三批药品符合中国药典标准,药物含量平均为77.91±1.63μg/次,每瓶185±3次.
结论:
- 成功开发了一种稳定可靠的酸计量剂量吸入器 (CA-MDI) 配方.
- 优化的CA-MDI配方显示出有效的向向肺部输送的潜力,用于呼吸道同胞病毒 (RSV) 治疗.
- 开发的配方符合严格的质量标准,为进一步的临床研究铺平了道路.
更多相关视频
09:01An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
09:14An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay
Published on: January 26, 2019
相关概念视频
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Drugs Used in Lower Respiratory Disorders: Overview
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Drugs Used in Upper Respiratory Disorders: Overview
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Acute Respiratory Failure-IV
