北欧步行对阿尔茨海默病的影响:一项单盲随机对照临床试验
A Angiolillo1, D Leccese1, S Ciccotelli1
1Centre for Research and Training in Medicine for Aging, Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, 86100, Campobasso, Italy.
Heliyon
|June 12, 2023
概括
北欧步行 (NW) 在改善阿尔茨海默氏症患者的记忆和注意力等认知功能方面表现有前途.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 康复医学 康复医学 康复医学
背景情况:
- 身体不活动是阿尔茨海默病 (AD) 和心血管疾病的重要可改变的风险因素.
- 包括运动在内的非药物干预措施正在探索,以管理AD的认知和行为症状.
- 北欧步行 (NW) 有益于老年人群,但其在阿尔茨海默病患者中的有效性尚未得到充分研究.
研究的目的:
- 调查北欧步行 (NW) 对轻度/中度阿尔茨海默病 (AD) 患者认知领域的影响.
- 评估NW对执行功能,视觉空间能力和口头情节性记忆的影响.
主要方法:
- 一项试点研究涉及30名患有轻度/中度AD的患者.
- 一个实验组 (EG) 接受标准疗法加NW每周两次,持续24周.
- 对照组 (CG) 仅接受标准疗法24周.
- 神经心理评估在基线和24周后进行.
主要成果:
- 与CG相比,EG在执行功能 (正面评估电池) 和口头情节性记忆 (雷的听觉口头学习测试延迟回忆) 中显著改善.
- 在EG中观察到增强的视觉空间推理 (雷文的彩色渐进矩阵) 和处理速度 (Stroop Word-Color干扰测试).
- 在阿尔茨海默病患者中,NW对视觉空间能力,口头情节性记忆,选择性注意力和处理速度产生了积极的影响.
结论:
- 北欧步行 (NW) 似乎是一种安全且潜在的有益的非药物策略,用于改善轻度/中度阿尔茨海默病 (AD) 的认知功能.
- 需要对更大的队列和更长时间进行进一步的研究来证实这些发现.
- NW可能有助于减缓患有早期AD的个体的认知衰退.
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