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一个新的瘤移植面板,以加速前列腺癌的精准医学

Claire Béraud¹, Nadege Bidan¹, Myriam Lassalle¹

¹Urosphere, Toulouse, France.

Frontiers in oncology

|June 12, 2023

概括

我们开发了五种新的患者衍生异种移植模型,代表前列腺癌 (PCa) 的不同阶段,包括神经内分泌PCa. 这些模型显示了对治疗的多种反应,并为推进PCa研究和治疗开发提供了宝贵的资源.

科学领域:

在瘤学瘤学.
遗传学遗传学是一个
翻译研究是翻译研究.

背景情况:

尽管治疗进展,转移性前列腺癌 (PCa) 仍然是无法治愈的.
临床前模型对于理解PCa异质性和开发精密疗法至关重要.
患者衍生异种移植 (PDX) 模型为研究复杂瘤生物学提供了一个平台.

研究的目的:

建立和描述一个代表前列腺癌不同阶段的PDX模型生物库.
评估这些模型在临床前药物测试中的有用性.
为前列腺癌研究提供一个宝贵的资源.

主要方法:

获取前列腺癌患者的新鲜瘤样本.
组织学和STR概况分析,以确认模型的可靠性.
对抗雄激素缺乏,化疗和PARP抑制剂的PDX模型反应的评估.

主要成果:

开发了五种新的PDX模型,包括先前没有使用过激素的,对雄激素敏感的,抵抗割的 (CRPC) 和神经内分泌的CRPC (CRPC-NE) 阶段.
基因组表征揭示了雄激素信号传递,DNA修复和PI3K通路中的驱动因素变化.
PDX模型对治疗产生异质反应,反映了患者的结果;CRPC-NE模型对PARP抑制剂产生反应.

结论:

建立了一个有价值的生物库,包括前列腺癌的五个PDX模型.
模型中的基因组和代谢变化与治疗耐药性相关.
CRPC-NE PDX 模型对 PARP 抑制剂治疗具有前景,为前列腺癌治疗研究提供了一条新的途径.

关键词:

这是一种PARP抑制剂.这是PDX PDX.割抗性前列腺癌 (CRPC) 是一种癌症.基因组特征基因组特征代谢过程中的代谢.这是神经内分泌瘤.前列腺癌是前列腺癌.瘤异质性的异质性

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