皮质醇是成年男性勃起功能障碍的内源调解剂吗?
Harrina E Rahardjo1,2, Armin J Becker3, Viktoria Märker4
1Department of Urology, University of Indonesia, School of Medicine, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Translational andrology and urology
|June 12, 2023
概括
皮质醇水平在健康男性的性兴奋期间下降,但在勃起功能障碍 (ED) 的男性中保持不变. 这表明皮质醇可能会对男性的性反应产生敌意,其失调可能会导致ED.
科学领域:
- 内分泌学 在内分泌学.
- 男人性健康 男人性健康
- 生理学 生理学 生理学
背景情况:
- 长期以来,上腺皮质类固醇在男性性功能 (包括兴奋和勃起) 中的作用一直在争论中.
- 上腺皮质转移轴对阴茎勃起的影响需要进一步调查.
研究的目的:
- 在各种性兴奋阶段确定洞穴和全身血液中的皮质醇水平.
- 为了比较健康男性和勃起功能障碍 (ED) 患者之间的这些水平.
主要方法:
- 54名健康男性和45名ED患者暴露于视觉性刺激.
- 血液样本从阴茎洞体 (CC) 和足静脉 (CV) 采集在软,缩,刚性和脱时.
- 血清皮质醇使用放射免疫测定 (RIA) 量化.
主要成果:
- 在健康的男性中,在性刺激后,皮质醇在CV和CC血液中降低.
- 在解过程中,全身皮质醇保持稳定,而CC皮质醇进一步下降.
- 在ED患者中,系统性或洞穴性皮质醇水平没有显著变化.
结论:
- 皮质醇可能会作为男性性反应周期的对手.
- 皮质醇分泌或降解的失调可能与ED的病理生理学有关.
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