相关实验视频
Updated: Jul 26, 2025

09:12
MISSION LentiPlex Pooled shRNA Library Screening in Mammalian Cells
Published on: December 21, 2011
18.7K
人类癌症中的Circ-SHPRH:系统性审查和元分析
Hong Xiong1, Gaozhen Huang1, Yi Zhu1
1Laboratory of Urology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Frontiers in cell and developmental biology
|June 12, 2023
概括
循环RNA特别是circ-SHPRH在癌症发展中起着关键作用. 高circ-SHPRH表达与癌症患者的更好的整体存活率和较低的瘤阶段有关.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 循环RNA (circRNAs) 是具有独特环状结构的非编码RNA.
- 新出现的证据表明,circRNAs与瘤发生和癌症转移有关.
- 来自SHPRH基因的Circ-SHPRH因其与各种人类癌症的关联而越来越受认可.
研究的目的:
- 对关于circ-SHPRH在人类癌症中的作用的现有文献进行审查和元分析.
- 阐明circ-SHPRH在瘤学环境中的诊断和预后潜力.
主要方法:
- 在PubMed,Web of Science和Embase数据库中进行系统的文献搜索,直到2022年12月24日.
- 包括18篇相关的研究论文,其中11篇被选中进行元分析.
- 对专注于瘤诊断,整体存活率 (OS) 和瘤等级的研究进行分析.
主要成果:
- 分析显示,高的circ-SHPRH表达与更好的OS (HR = 0.53) 和较低的TNM阶段 (HR = 0.33) 相对应.
- 圆形SHPRH作为miRNA海绵或蛋白质编码分子起作用,影响癌细胞的增殖,入侵和亡.
- 循环SHPRH显示出显著的诊断潜力,AUC为0.8357.
结论:
- 环SHPRH在癌细胞的生物功能中起着至关重要的作用.
- 高circ-SHPRH表达是固体癌症的有利预后指标.
- 作为人类癌症的新型诊断和预后生物标志物,Circ-SHPRH具有前途.
更多相关视频
相关概念视频
Cancer Therapies
7.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.8K
Cancer Survival Analysis
402
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
402
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Hazard Ratio
166
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
166
Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K

