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Updated: Jul 26, 2025

Using RNA-mediated Interference Feeding Strategy to Screen for Genes Involved in Body Size Regulation in the Nematode C. elegans
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内膜载体对Caenorhabditis elegans中的系统性RNAi进行负面调节

Katsufumi Dejima1, Rieko Imae1, Yuji Suehiro1

  • 1Department of Physiology, Tokyo Women's Medical University School of Medicine, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.

iScience
|June 12, 2023
PubMed
概括

研究人员发现,ZIPT-9是一种载体,在C. elegans中充当系统性RNA干扰 (RNAi) 的负调节者. 这一发现揭示了载体在调节基因沉默通路中的新作用.

关键词:
细胞生物学 细胞生物学分子生物学分子生物学

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In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
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