暂时食用西方饮食训练免疫系统,以减少未来的肠道炎症
Dongwen Wu1,2, Xiaotong Wang1,2, Xiang Yang3
1Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
iScience
|June 12, 2023
概括
暂时的西方饮食 (WD) 消费,然后进行正常饮食,可以扭转负面的健康影响并训练免疫系统. 这种饮食模式令人惊地减少了炎症并增强了肠道屏障功能.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 城市化促进了西方饮食 (WD) 的消费,与增加的代谢和炎症性疾病有关.
- 不断摄入WD会破坏肠道屏障,导致轻度炎症并加剧结肠炎.
- 了解饮食对肠道健康和免疫的影响对于公共健康至关重要.
研究的目的:
- 调查过渡性饮食消费,其次是正常饮食对肠道屏障完整性和炎症反应的影响.
- 为了确定短期WD摄入是否可以诱导对大肠炎的保护性免疫训练.
- 探索所观察到的保护作用背后的机制.
主要方法:
- 给小鼠了一种连续的WD,过时的WD,然后是正常的饮食,或正常的饮食.
- 通过测量粘素生产和紧密结合蛋白表达来评估肠道屏障功能.
- 通过使用硫酸 (DSS) 诱导的大肠炎和Citrobacter rodentium感染模型来评估炎症反应.
- 机理学研究涉及分析胆固醇生物合成途径和巨细胞活动.
主要成果:
- 与连续的WD相比,短暂的WD消费增强了粘素的产生和紧结蛋白的表达.
- 过渡性WD暴露的小鼠在DSS和C. rodentium大肠炎模型中显示出减少的炎症反应.
- 保护作用独立于性别,不能归因于微生物群的变化.
- 确定了胆固醇生物合成途径和巨细胞的关键作用,这表明先天的髓状细胞训练.
结论:
- 消费WD的有害影响可以通过恢复更健康的饮食来减轻.
- 暂时的WD消费赋予有益的免疫训练,可能是进化适应食物丰富时期的进化适应.
- 这表明了饮食干预的新策略,以增强肠道健康和对炎症的抵抗力.
更多相关视频
09:31Effects of Taste Signaling Protein Abolishment on Gut Inflammation in an Inflammatory Bowel Disease Mouse Model
Published on: November 9, 2018
8.7K
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
12.3K
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
362
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
362
01:23Anatomy of the Intestines
72.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.6K
01:50What is Monogastric Digestion?
71.7K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.7K