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血清标志物的预测价值在新生儿死性肠球炎的操作评估中
1Department of Surgery, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Translational pediatrics
|June 12, 2023
概括
血清标记物如C反应蛋白 (CRP) 和前素 (PCT) 可以帮助确定新生儿死性肠球炎 (NEC) 的手术时间. 较高的CRP,IL-6,SAA,PCT和I-FABP水平表明NEC患者需要进行手术干预.
科学领域:
- 儿科手术 儿科手术
- 新生儿医学 新生儿医学
- 胃肠病学 胃肠病学
背景情况:
- 新生儿死性肠球炎 (NEC) 是新生儿的关键性胃肠道疾病,其病因不明.
- 确定NEC的最佳手术时间对于改善患者的治疗结果至关重要.
研究的目的:
- 评估血清标记物的临床实用性,以指导NEC手术决策.
- 评估NEC手术干预的特定生物标志物的诊断准确性.
主要方法:
- 对150名NEC患者的回顾性分析,分为手术 (n=58) 和非手术 (n=92) 组.
- 测量了血清度的C-反应蛋白 (CRP),介质素-6 (IL-6),血清粉样蛋白A (SAA),甲素 (PCT),以及肠脂肪酸结合蛋白 (I-FABP).
- 利用后勤回归和ROC曲线分析来确定NEC手术中的血清标记物的预测值.
主要成果:
- 与非手术组相比,在NEC操作组中观察到CRP,I-FABP,IL-6,PCT和SAA的升高水平 (P<0.05).
- 这些血清标记被确定为与NEC手术治疗需要相关的独立因素.
- 对于CRP (0.805),PCT (0.844),IL-6 (0.635),I-FABP (0.872) 和SAA (0.864) 的ROC分析显示了曲线下的显著区域 (AUC),表明它们在预测外科手术的必要性方面的潜力.
结论:
- 包括CRP,PCT,IL-6,I-FABP和SAA在内的血清标记物具有宝贵的指导实用性,用于确定儿科NEC手术干预的最佳时间.
- 这些生物标志物可以帮助临床医生做出有关NEC手术管理的明智决策.
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