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黄昏症,体外受精和早产风险:基于2,880,759个样本的回顾性队列研究
Jing Wang1, Jiansong Yin1, Mei Xue1
1Department of Neonatology, Changzhou No. 2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.
Translational pediatrics
|June 12, 2023
概括
阴和体外受精 (IVF) 协同增加了早产风险. 接受试管婴儿的妇女应该意识到这种综合风险,以更好地管理怀孕.
科学领域:
- 产科和妇科 产科和妇科
- 生殖医学 生殖医学
- 产周研究 产周研究
背景情况:
- 黄昏症和体外受精 (IVF) 是早产的已知独立风险因素.
- 了解综合风险因素对于准确预测早产至关重要.
- 这项研究探讨了阴和试管婴儿在早产风险上的相互作用.
研究的目的:
- 探索生和体外受精 (IVF) 之间的协同作用,增加早产风险.
- 量化催产素和试管婴儿对早产产生的联合影响.
- 为孕妇个性化风险评估提供见解.
主要方法:
- 来自2019年国家生命统计系统 (NVSS) 数据库的2,880,759名参与者的回顾性队列研究.
- 后勤回归模型被用来评估阴,试管婴儿和早产之间的关联.
- 通过使用相对过度风险因相互作用 (RERI),可归因比例 (AP) 和协同指数 (S) 来评估相互作用.
主要成果:
- 早产的发病率在阴症组为37.31%,在试管婴儿组为22.96%.
- 患有黄昏症和试管婴儿的个体表现出明显更高的早产风险 (OR = 9.197).
- 关于早产的生殖和试管婴儿之间发现了具有统计意义的协同作用 (RERI = 3.426,S = 1.723).
结论:
- 阴和试管婴儿有协同作用,大大增加了早产的风险.
- 接受试管婴儿的孕妇应该意识到,当出现黄昏症时,风险会增加.
- 饮食和生活方式的修改可能对接受试管婴儿的孕妇至关重要,以减轻早产风险.
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