内分类素系统组件作为 tinnitus 中潜在的神经免疫治疗点
Vishweshwara Bhat1, Emmanuel Shan Onaivi2, Venkatanarayanan Sharma2
1Speech Language Pathology, William Paterson University, Wayne, NJ, United States.
Frontiers in neurology
|June 12, 2023
概括
对耳的研究越来越多,重点是内分泌系统 (ECS). 这一观点突出了CB2受体配体作为耳治疗标的潜力,特别是在COVID-19的背景下.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 审计科学 审计科学
背景情况:
- 耳是一个普遍的听力障碍,经常伴随着听力损失和超音量.
- 听觉大脑干中的神经元过度活动是 tinnitus 的一种拟议机制.
- 由于大麻合法化日益增加,内分泌大麻系统 (ECS) 和它在包括耳在内的各种健康障碍中的作用正受到越来越多的关注.
研究的目的:
- 探索内分泌系统 (ECS),特别是CB2受体 (CB2Rs) 在听觉系统的神经免疫功能中的新兴作用.
- 提出ECS/CB2R途径作为声的潜在药物基因组治疗标.
主要方法:
- 对耳,ECS和听觉系统中的大麻素受体 (CBR) 的现有研究进行了审查.
- 对以往研究的分析,重点是CB1R配体及其在声模型中的有限有效性或有害影响.
- 考虑新的分子和转基因技术来剖析ECS的复杂性.
主要成果:
- 大麻素受体 (CBR) 存在于听觉系统中,这表明ECS参与听觉和耳.
- 以前的研究主要集中在CB1Rs上,在治疗耳方面取得的成功有限.
- 新出现的证据表明,ECS/CB2R在听觉系统中的神经免疫功能.
结论:
- 电脑神经系统的神经免疫交叉声,特别是涉及CB2Rs,代表了对耳有前途的治疗途径.
- 用特定的配体向CB2Rs可能为耳治疗提供一种新的药物基因组策略.
- 这种方法在当前时代尤其重要,考虑到耳与COVID-19的关联.
相关概念视频
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
327
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
327
Analgesia and Pain Management
668
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
668
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
272
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
272
Opioid Receptors: Overview
1.1K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
1.1K
G Protein-coupled Receptors
12.3K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
12.3K
Ligand-Gated Ion Channel Receptor: Gating Mechanism
2.3K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
2.3K


