高风险基因型与印度妇女对受控卵巢刺激的反应不佳有关
Anuradha Udumudi1, K Chaitra Lava1, Vandana Hegde2
1GeneTech, Hyderabad, Telangana, India.
Journal of human reproductive sciences
|June 12, 2023
概括
鉴定了经过体外受精 (IVF) 的印度妇女对受控卵巢刺激 (COS) 反应的遗传标志物. 这些发现为预测试管婴儿成功和改善患者结果提供了潜力.
科学领域:
- 遗传学 是一个遗传学.
- 生殖医学 生殖医学
- 基因组学就是基因组学.
背景情况:
- 不孕症是一个日益严重的全球健康问题,需要辅助生殖技术,如体外受精 (IVF).
- 控制性卵巢刺激 (COS) 是试管婴儿的一个关键组成部分,患者的反应差异很大.
- 印度人口中COS反应的遗传基础在很大程度上仍未被探索.
研究的目的:
- 研究受控卵巢刺激 (COS) 响应在接受试管婴儿的印度人口中的基因组基础.
- 识别可以预测患者对COS的反应的遗传标记.
- 确定这些基因标记物对试管婴儿结果的预测价值.
主要方法:
- 在印度海德拉巴德招募了312名女性 (212名不育患者,100名对照) 的队列.
- 用下一代测序来分析与COS反应相关的基因.
- 进行了统计分析,包括赔率比,以确定标记者的显著性.
主要成果:
- 在特定基因变异 (AMH,AMHR2,ESR1,FSHR,LHCGR) 与不孕症或COS反应之间发现了显著的关联.
- 综合风险分析确定了整合遗传标记和生物化学参数的潜在预测因素.
- 发现的关键遗传变异包括AMH的c.146G>T,AMHR2的c.622-6C>T,ESR1的c.453-397T>C和c.975G>C,FSHR的c.2039G>A和LHCGR的c.161+4491T>C.
结论:
- 这项研究成功地确定了在印度人口中预测受控卵巢刺激 (COS) 反应的潜在遗传标记.
- 这些标记在试管婴儿治疗中对个性化医疗方法具有前景.
- 进一步的研究可以验证这些发现,并将其纳入临床实践,以提高试管婴儿成功率.
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