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复杂生物矩阵中的二:关于预处理和检测方法的最新更新

Yi-Xin Zhang¹, Yuan Zhang¹, Yu Bian¹

¹School of Pharmacy, China Medical University, Shenyang, 110122, China.

Journal of pharmaceutical analysis

|June 12, 2023

概括

本综述涵盖了最近在生物样本中检测二类药物 (BDZs) 的方法方面的进展. 它强调了这些常常被滥用的药物的高效预治疗和检测策略.

科学领域:

法医化学法医化学
分析化学分析化学
药理学药理学是指药理学的学科.

背景情况:

二类药物 (BDZs) 广泛用于缓解焦虑,抗,镇静剂和肌肉松作用.
全球高消费和成潜力导致滥用自杀和犯罪活动,如药物促进性侵犯.
在复杂的生物矩阵中检测低剂量BDZ存在重大分析挑战.

研究的目的:

审查提取,丰富和预先缩 BDZs 的预处理方法.
总结最近用于选,识别和定量 BDZ 的策略.
讨论BDZ检测方法的特点,优势和未来方向.

主要方法:

检查提取技术,包括固相提取 (SPE) 和液相提取 (LPE).
分析染色学方法,如高性能液体染色学 (HPLC) 和气体染色学 (GC).
检查基于质谱 (MS) 的检测技术,包括LC-MS/MS和GC-MS/MS.

主要成果:

最近的进展重点是提高BDZ检测的灵敏度,选择性和速度.
新的提取和丰富技术提高了复杂的基质如血液,尿液和头发的恢复率.
经过验证的方法可以在微量水平上准确识别和量化 BDZ.

结论:

有效的预处理和敏感的检测方法对于解决BDZ滥用至关重要.
对于法医和临床毒理学,分析技术的持续发展是必要的.
未来的研究应该专注于快速,便携式和具有成本效益的 BDZ检测解决方案.

关键词:

二胺类药物的使用.生物矩阵是生物矩阵.检测方法检测方法样品的准备样品的准备

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