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隐藏的乙型肝炎在献血中心

Yazan AlRashdan¹, Khalid Al-Jaff¹, Manal Najdawi²

¹Department of Pharmacy, Faculty of Pharmacy, Amman Arab University, Amman, Jordan.

Journal of medicine and life

|June 12, 2023

概括

隐性乙型肝炎 (OHB) 在巴斯拉献血者中占比21.6%. 具有OHB阳性的供体对乙型肝炎病毒 (HBV) 呈现免疫反应,突出显示了输血传播风险.

科学领域:

肝病学肝病学是一种肝病学.
免疫学免疫学免疫学
输血医学输血医学

背景情况:

隐性乙型肝炎 (OHB) 涉及没有表面抗原 (HBsAg) 的乙型肝炎病毒 (HBV) DNA 存在.
高血压带来了输血传播的HBV的风险,特别是在献血者身上.
伊拉克巴斯拉的OHB的流行率和免疫特征仍然没有被描述.

研究的目的:

在伊拉克巴斯拉的献血者中确定OHB的患病率.
研究OHB阳性捐赠者的免疫反应,包括免疫球蛋白和补充剂水平.
评估对输血安全和诊断策略的影响.

主要方法:

招募了450名献血者,根据HBV血清标志物对其进行分类.
在OHB阳性个体中测量IgG,IgM,补充成分 (C3,C4),ALT,AST和血清ALP.
分析了血清学数据,以比较不同供体组的免疫标记物.

主要成果:

确定OHB的发病率为21.6% (97名450名捐赠者中).
有OHB阳性的捐赠者显示IgG水平明显高于IgM水平.
患者的C3水平高于健康和HBsAg阴性/HBsAb阳性捐赠者;患者组的血清ALP升高.

结论:

巴斯拉的高OHB患病率需要加强查协议.
具有OHB阳性的捐赠者对HBV表现出明显的免疫反应.
这些发现为预防输血传播的HBV和管理OHB的战略提供了信息.

关键词:

标志着HBV病毒的标志物在IgG IgG的基础上.补充组件 (C3和C4) 的组件.血清中的ALP水平.

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