两动物的感染耐受性对奇特菌菌的感染耐受性
Laura F Grogan1, Madelyn J Mangan1, Hamish I McCallum1
1Centre for Planetary Health and Food Security, and School of Environment and Science, Griffith University, Gold Coast Campus, Parklands Drive, Southport, Queensland 4222, Australia.
概括
两动物可以通过耐受性,限制疾病影响,以及抵抗性,限制感染强度来对抗菌菌. 了解耐受性是缓解这种真菌病的关键.
科学领域:
- 生态免疫学 生态免疫学
- 疾病生态学 疾病生态学
- 两动物保护协会
背景情况:
- 动物对感染的防御包括耐受性 (限制疾病影响) 和抵抗性 (限制感染强度).
- 耐受性对于特有疾病至关重要,因为在这些疾病中,耐药性不那么有效.
- 为两动物耐受 *Batrachochytrium* spp. 的选择性繁殖. (甲状腺炎) 是一个拟议的缓解策略.
研究的目的:
- 定义和区分感染耐受性和耐药性在菌菌病的背景下.
- 提供证据,证明耐受性对菌菌菌的变化.
- 探索耐受性致菌病的流行病学,生态学和进化学影响.
主要方法:
- 对两动物对*Batrachochytrium* spp.耐受性和耐药性的现有知识的审查和综合.
- 对影响感染负担的流行病学因素的分析.
- 探索与耐受性和抵抗性相关的生态权衡和进化动态.
主要成果:
- 暴露风险和环境因素严重影响了对耐药性和耐受性的评估.
- 囊性菌症的特点是构成性抵抗的变化,而不是适应性抵抗.
- 耐受性在病原体的传播和维持中起着至关重要的作用;耐受性的异质性会产生生态权衡,耐药性/耐受性的选择可能会被稀释.
结论:
- 了解两动物对感染的耐受性对于管理菌菌病至关重要.
- 耐受性影响疾病动态,影响病原体的传播和宿主生存.
- 对耐受性知识的提高扩大了缓解野生动物新兴传染病的策略.
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