免疫的本体性和潜在的共感染的潜在影响
1Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46656, USA.
概括
宿主免疫力随着年龄的增长而变化,影响寄生虫的相互作用. 变形青对Batrachochytrium dendrobatidis (Bd) 真菌的抵抗力较低,原因是免疫力下降,影响了他们的健康.
科学领域:
- 两动物免疫学 两动物免疫学
- 生态免疫学 生态免疫学
- 寄生虫与宿主之间的相互作用
背景情况:
- 两动物生命阶段的免疫力各不相同,特别是在变形过程中,影响对共感染寄生虫的反应.
- 大多数免疫记忆在两生物转型过程中会丢失,这可能会改变免疫防御的复杂性.
- 免疫的本体遗传变化可以调解同时感染寄生虫物种之间的相互作用.
研究的目的:
- 为了研究宿主免疫本体产生如何影响共感染寄生虫之间的相互作用在古巴树.
- 为了确定是否同时暴露于真菌 (Batrachochytrium dendrobatidis,Bd) 和线虫 (Aplectana hamatospicula) 在不同生命阶段会影响宿主免疫力和健康.
- 为了测试共感染促进寄生虫相互作用的假设,由于同时增加免疫反应的能量需求.
主要方法:
- 同时暴露于,变形和后变形的古巴树 (Osteopilus septentrionalis) 的Bd和A. hamatospicula.
- 测量宿主免疫指标 (IgY水平,细胞免疫),宿主健康指标和寄生虫的数量.
- 评估免疫反应和寄生虫驱动相互作用中的本体遗传差异.
主要成果:
- 观察到IgY水平和细胞免疫力的本体遗传差异,但与相比,变形青没有表现出一般免疫抑制.
- 很少有证据支持Bd和A. hamatospicula之间的促进相互作用,而A. hamatospicula没有改变宿主免疫力或健康.
- 与其他生命阶段相比,Batrachochytrium dendrobatidis (Bd) 感染降低了变形青的免疫力,降低了它们对Bd的耐药性和耐受性.
结论:
- 在本体发生过程中宿主免疫的变化显著改变了对寄生虫暴露的反应.
- 变形阶段的两动物对像Bd.这样的免疫抑制病原体具有独特的脆弱性.
- 这项研究强调了考虑宿主生命阶段的重要性,以了解两动物疾病动态和寄生虫生态.
关键词:
巴特拉科希特 (Batrachochytrium dendrobatidis) 是一种类型的植物.两动物两动物免疫力是一种免疫力.变形转化是一种转化.人类的本体生长过程 (ontogeny)权衡权衡权衡权衡权衡权衡权更多相关视频
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