麻醉症的心血管负担 (CV-BOND):一个真实世界的证据研究研究
Rami H Ben-Joseph1, Ragy Saad1, Jed Black1,2
1Jazz Pharmaceuticals, Palo Alto, CA, USA.
Sleep
|June 12, 2023
概括
麻醉症患者面临新发心血管事件的更高风险,包括中风和心力衰竭. 这项研究强调了在麻醉症患者中考虑心血管健康的重要性.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 麻醉症是一种慢性神经系统疾病,影响睡眠和清醒周期.
- 现有研究表明,麻醉症与心血管风险因素有关.
- 麻醉症患者新发性心血管事件的具体风险尚不清楚.
研究的目的:
- 为了评估美国成年人被诊断患有麻醉症的新发性心血管事件的过度风险.
- 为了比较麻醉症患者和匹配的对照组之间的心血管事件发生率.
主要方法:
- 使用IBM MarketScan行政索赔数据 (2014-2019) 进行的回顾性队列研究.
- 将麻醉症队列 (N=12,816) 与非麻醉症对照队列 (N=38,441) 相匹配,比例为1:3.
- 多变量考克斯比例危险模型被用于计算调整的危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 麻醉症队列对几种心血管事件的风险明显更高.
- 观察到任何中风 (HR 1.71),心力衰竭 (HR 1.35),缺血性中风 (HR 1.67) 和主要不良心脏事件 (HR 1.45) 的风险增加.
- 此外,对于包括中风,心房动或水 (HR 1.48) 和整体心血管疾病 (HR 1.30) 在内的集体事件也注意到风险增加.
结论:
- 麻醉症的成年人患有新发性心血管事件的风险增加.
- 医疗保健提供者应主动评估和管理麻醉症患者的心血管风险.
- 这一发现强调了对麻醉症患者综合护理方法的需要.
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