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工程磁触细菌MVs协同化疗,铁和免疫疗法用于增强抗瘤疗法

Gexuan Jiang^1,2, Zhichu Xiang¹, Qiaojun Fang^1,2,3

¹Laboratory of Theoretical and Computational Nanoscience, CAS Key Laboratory of Nanophotonic Materials and Devices, CAS Key Laboratory of Nanophotonic Materials and Devices, CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Ambient Particles Health Effects and Prevention Techniques, National Center for Nanoscience and Technology, Beijing 100190, China. xiangzhichu2021@163.com.

Nanoscale horizons

|June 12, 2023

概括

这项研究引入了一种新的纳米疫苗平台,使用带有多克索鲁比 (DOX) 和铁离子的细菌膜囊泡 (BMV). 这种纳米疫苗有效地结合了化疗,铁化疗和免疫疗法,用于增强癌症治疗,包括耐药瘤和转移.

科学领域:

生物技术和纳米医学
癌症治疗癌症治疗
免疫学免疫学免疫学

背景情况:

免疫抑制性瘤微环境阻碍了向癌症治疗和免疫疗法的有效性.
与单一治疗相比,组合治疗,特别是免疫疗法,显示出更好的结果.
细菌膜囊泡 (MVs) 是有前途的纳米载体,因为它们的免疫性和药物输送能力.

研究的目的:

开发一种新的纳米疫苗平台,用于同时进行化疗,铁灭疗法和免疫疗法.
使用带有多克索鲁比 (DOX) 和铁离子的细菌膜囊泡 (BMV) 制造一个协同作用的纳米疫苗.
为了增强瘤特异性和减少使用质修饰BMVs的毒性.

主要方法:

使用多克索鲁比 (DOX) 培养磁性细菌,以产生含有铁离子和DOX (BMV@DOX) 的专用MV (BMV).
用DSPE-PEG-cRGD基对BMV@DOX进行修改,以创建目标囊泡 (T-BMV@DOX).
在4T1乳腺癌,耐药MCF-7/ADR瘤和4T1-Luc诱导的小鼠肺转移模型中评估治疗疗效.

主要成果:

BMV@DOX有效地通过铁离子传递化学疗法和诱导铁亡的DOX,而BMVs刺激了天生的免疫力.
T-BMV@DOX证明了系统毒性最小化和瘤特异性的增强.
该纳米疫苗系统在治疗4T1乳腺癌,耐药MCF-7/ADR瘤和废除肺转移方面表现出卓越的疗效.

结论:

开发的基于MVs的纳米疫苗平台为癌症治疗提供了一个有希望的协同方法.
这种纳米平台有效地结合了化疗,铁和免疫疗法,克服了单一疗法的局限性.
这项研究表明,该纳米疫苗在临床应用中对各种癌症类型进行进一步研究的潜力.

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