网络解剖学在原发性渐进性失言症的logopenic变体中
Maria Luisa Mandelli1, Diego L Lorca-Puls1,2, Sladjana Lukic1,3
1Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA.
Human brain mapping
|June 12, 2023
概括
逻辑变异性初级渐进性失语症 (lvPPA) 脑缩开始于特定区域,并通过不同的网络传播. 健康大脑中的网络连接预测了lvPPA的进展,为疾病途径提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 逻辑变异性初级渐进性失言症 (lvPPA) 是一种神经退行性综合征.
- 它的特点是词重复和命名能力的逐渐下降.
- 这种下降与左后部和下部区域的缩有关.
研究的目的:
- 在lvPPA中识别最初的皮质疾病中心.
- 为了调查缩是否通过预定义的大脑网络传播.
- 为了确定功能连接是否预测缩进展.
主要方法:
- 使用了来自lvPPA患者的横截面结构MRI数据.
- 使用基于表面的分析和HCP-MMP1.0地图书来定义疾病中心.
- 结合了来自对照组的横截面fMRI数据和来自lvPPA患者的纵向MRI数据,以分析静止状态网络和缩传播.
主要成果:
- 确定了两个不同的lvPPA相关的大脑网络,它们来自左前角环和后上环.
- 这些网络与句子重复和命名缺陷有关.
- 在健康个体中,这些网络内的更强的功能连接在lvPPA患者中预测了更大的纵向缩进展.
结论:
- 在lvPPA中,缩起源于下面的头顶和顶接口区域.
- 疾病的进展至少遵循两个截然不同的,部分不重叠的路径.
- 这些途径可以解释临床表现和患者预后的变化.
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