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在婴儿患入侵性B型 estreptococcal 感染后的死亡率和神经发育结果
Maren Mynarek1, Torstein Vik1, Guro L Andersen1,2
1Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Developmental medicine and child neurology
|June 12, 2023
概括
在婴儿中侵袭性B型 estreptococcal (GBS) 感染导致显著的死亡率和长期神经发育障碍 (NDD) 在幸存者. 早期检测和干预对于受影响的儿童至关重要.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 神经发育障碍 神经发育障碍
背景情况:
- 侵袭性B型链球菌 (GBS) 感染对婴儿健康构成重大威胁.
- 包括神经发育障碍 (NDD) 在内的GBS感染的长期后果需要彻底调查.
研究的目的:
- 为了评估病例死亡率 (CFR),婴儿死亡率和婴儿入侵性GBS感染后长期神经发育障碍 (NDD) 的发生率.
- 在受影响儿童中确定与GBS脑膜炎相关的特定NDD.
主要方法:
- 一项基于人口的队列研究包括1996年至2019年期间在挪威出生的婴儿.
- 从国家登记处提取数据,将GBS感染诊断与死亡率和NDD结果联系起来,平均年龄为12岁10个月.
主要成果:
- 侵入性GBS感染的病例死亡率 (CFR) 为5.0%.
- 患有GBS感染的婴儿患婴儿死亡率 (RR 19.41) 和NDD (RR 3.49) 的风险明显更高.
- 在幸存者中,有20.7%被诊断为NDD,其中GBS脑膜炎与ADHD,脑,,听力障碍和发育障碍密切相关.
结论:
- 婴儿期的侵入性GBS感染导致大量的死亡率和长期的神经发育后果.
- 这些发现凸显了对GBS感染的婴儿和幸存者加强预防策略和早期干预途径的迫切需要.
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