对检查点抑制剂诱导的的回顾性多中心队列研究,重点关注管理
Chryssoula Papageorgiou1, Elizabeth Lazaridou1, Konstantinos Lallas2
1Second Dermatology Department, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Photodermatology, photoimmunology & photomedicine
|June 12, 2023
概括
免疫检查点抑制剂 (ICI) 诱导的影响了22%的患者,经常伴有其他皮肤毒性. 目前的治疗方法是有效的,窄带UVB光疗显示出作为一种类固醇节省选择的希望.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 有限的数据存在于免疫检查点抑制剂 (ICI) 诱导的.
- 对于ICI诱导的的各种管理策略的有效性尚未得到充分证实.
研究的目的:
- 描述ICI引起的的数量和质量方面.
- 评估ICI诱导的的常见治疗干预措施的有效性.
主要方法:
- 对91名接受ICI治疗的患者进行了回顾性审查,这些患者患有.
- 对的特征,同时发生的毒性和治疗结果的分析.
主要成果:
- 22%的患者经历作为唯一的症状;78%的患者同时存在皮肤毒性.
- 第一线治疗包括抗组胺剂和局部治疗方案.
- 窄带UVB (NBUVB),口服类固醇和GABA类似物用于耐药病例.
- 治疗后观察到的数值评分表 (NRS) 评分显著降低,特别是光疗.
结论:
- 作为一个独立的症状发生在22%的研究队列.
- 目前用于ICI诱导的的治疗策略是有效的.
- NBUVB光疗为管理ICI诱导的提供了一个潜在的类固醇节约替代方案.
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