胞在脂质体系统获得的可纳比输送的proliposomal方法:结构特征和皮肤透
Silvia Franzè1, Caterina Ricci2, Elena Del Favero2
1Department of Pharmaceutical Sciences, University of Milan, Via G. Colombo 71, Milan 20133, Italy.
Molecular pharmaceutics
|June 12, 2023
概括
这项研究开发了新型的益波体,用于增强大麻 (CBD) 的皮肤输送. 这些药物-in-micelles-in-liposome (DiMiL) 系统改善了CBD的透性和稳定性,用于局部应用.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 可变形的脂质体提供了皮肤药物传递的潜力,但患有药物泄漏.
- 质体和药物-在-微粒-在-脂质体 (DiMiL) 系统是改善脂质体稳定性和药物负载的策略.
- 与DiMiL相结合的普利波索姆可能会增强大麻 (CBD) 的皮肤透和配方稳定性.
研究的目的:
- 调查结合proliposomes和DiMiL系统的优势,以提高CBD的皮肤输送.
- 用不同的糖 (乳糖,糖,三糖) 和制备方法 (喷雾干燥,泥) 制备和描述proliposomes.
- 评估从开发的DiMiL配方中获得的CBD的皮肤透和释放概况.
主要方法:
- 通过喷雾干燥和泥方法,用不同糖/脂质比率的糖糖,三糖或乳糖制备了普利波索姆.
- 通过用含有CBD的Kolliphor HS 15微粒散液来水益素体形成DiMiL系统.
- 配方特性包括Cryo-EM,SAXS,可变性评估,以及使用人类表皮进行体外皮肤透研究.
主要成果:
- 在 2:1 的糖/脂质比率下,糖和三糖分别在喷雾干燥和化方法中产生了最佳的 proliposomes.
- 化-EM和SAXS证实了脂质体内菌体的存在以及DiMiL系统的结构完整性,不受糖的影响.
- 所有的DiMiL配方都表现出高的可变性和受控的CBD释放.
- 与传统的脂质体或油溶液相比,DiMiL系统显著增强了通过人类表皮的CBD透.
- 加入三糖进一步稍微增加了CBD的流量.
结论:
- 益波体作为有效的中间体,用于创建稳定,可变形的基于脂质体的局部配方.
- 开发的DiMiL系统显著改善了CBD的皮肤透,为皮肤药物输送提供了一个有前途的方法.
- 与DiMiL技术相结合的益波体增强了药物稳定性,而不会影响药物输送性能.
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